Dextran sulfate is a polyanionic derivative of dextran produced by esterification of Dextran with chlorosulphonic acid. Dextran sulfate sodium (DSS) is the sodium salt which is a white to off-white powder freely soluble in water and salt solutions to form a stable, clear solution. The sulfur content is approximately 17% which corresponds to an average of 1.9 sulfate groups per glucosyl residue of the dextran molecule. Dextran is a polymer of anhydroglucose. It is composed of approximately 95% alpha-D-(166) linkages. The remaining (163) linkages account for the branching of dextran.

Applications

Dextran Sulfate Sodium (DSS) which has proven to have versatile value in Biomedical/clinical research. DSS can be used to study Colitis (Inflammatory Bowel disease) as well as an antiviral as agent.

Inflammatory Bowel Disease (IBD) is characterized by chronic and relapsing inflammation of the gastrointestinal tract which is associated with increased risk of developing colitis-associated cancer. Several animal models have been used to study colitis and one such model involves the oral administration of dextran sodium sulfate (DSS) in the drinking water of mice leading to chronic colitis. This DSS induced colitis model is spontaneous and is used to assess the therapeutic potential of treatments for IBD.

Bamba et al (2012) performed a comparative analysis of 3 different DSS preparations to examine the chemical and cytotoxic properties as well as severity of colitis. Their study concluded that the DSS from MP Biomedicals induced a severe colitis as indicated by body weight transition, DAI score, colon weight/length and histological scores. This DSS is well characterized and offers the following advantages:
• Highest sulfur content – 19%
• Highest chirality - +104° of specific rotation
• Lowest pH – 6.2 at 1% solution

Cat#

Description

Pack Size

Remark

0216011001

DEXTRAN SULFATE SODIUM SALT (36,000-50,000 M.Wt.) Colitis Grade

1g

0216011010

DEXTRAN SULFATE SODIUM SALT (36,000-50,000 M.Wt.) Colitis Grade

10g

0216011025

DEXTRAN SULFATE SODIUM SALT (36,000-50,000 M.Wt.) Colitis Grade

25g

0216011050

DEXTRAN SULFATE SODIUM SALT (36,000-50,000 M.Wt.) Colitis Grade

50g

0216011080

DEXTRAN SULFATE SODIUM SALT (36,000-50,000 M.Wt.) Colitis Grade

100g

Best

0216011090

DEXTRAN SULFATE SODIUM SALT (36,000-50,000 M.Wt.) Colitis Grade

500g